Biorestructuring with salmon DNA polynucleotides: the regenerative treatment that Kim Kardashian is also talking about.
In recent months, there has been a lot of talk about regenerative aesthetic medicine and treatments that improve skin quality without altering its volume.
Among these, one of the most interesting is the biorestructuring with polynucleotides derived from salmon DNA, an advanced technology that I have long been using in my regenerative medicine protocols to improve skin tone, elasticity, and quality.
Public interest grew further after Kim Kardashian, in a recent interview also reported by Vanity Fair Italy, said she tried a salmon DNA-based skin treatment, helping to bring this technology to the general public.
But what are polynucleotides really and why are they becoming one of the most requested treatments in aesthetic medicine?
What are salmon DNA polynucleotides?
Polynucleotides are purified DNA fragments with strong regenerative and biostimulatory properties. In my clinical practice, they are used for specific purposes:
- Stimulate fibroblast activity
- To promote the production of collagen and elastin
- Improve deep hydration and skin quality
- Protect the skin from oxidative stress
The DNA used comes from salmon because it has a great biological affinity with human DNA, making it highly biocompatible and safe. The result is firmer, brighter, and healthier skin, without altering the features in the slightest.
Biorestructuring: What it really means
When I talk about skin biorestructuring, I am referring to a different concept than classic filling treatments. The goal is not to fill, but to regenerate the skin from within.
Through polynucleotides it is possible to make the skin more elastic and resistant, obtaining a glow effect Natural. It's a treatment I often recommend to patients who want natural results, without distorting their face.
Who do I recommend this treatment to?
Biorestructuring with polynucleotides is indicated for those who present:
- Dull or dehydrated skin
- Loss of tone and first signs of aging
- Skin stressed by the sun or pollution
- Need for prevention of skin aging
How the treatment is carried out
The treatment consists of superficial microinjections. The session lasts approximately 20–30 minutes and does not require significant recovery time. I generally recommend a protocol of 3–4 sessions to obtain a progressive result.
Regenerative aesthetic medicine: the future
In my clinical approach I often prefer to combine multiple technologies for perfect synergy:
- Polynucleotides and biostimulating hyaluronic acid
- Microneedling and Exosomes
The secret is not the single treatment, but the protocol
In my work, I strongly believe in personalized approaches. There is no one-size-fits-all treatment: every skin type requires a specific approach. Biorestructuring is one of the most effective tools, but the best results are always achieved through a personalized approach.


