Biorestructuring with polynucleotides from salmon DNA

Among the most innovative treatments is skin biorestructuring with salmon DNA polynucleotides, a therapy used in aesthetic medicine to stimulate tissue regeneration and visibly improve skin quality.

Polinucleotidi e Rigenerazione Cutanea
Regenerative Medicine

Biorestructuring with salmon DNA polynucleotides: the regenerative treatment that Kim Kardashian is also talking about.

In recent months, there has been a lot of talk about regenerative aesthetic medicine and treatments that improve skin quality without altering its volume.

Among these, one of the most interesting is the biorestructuring with polynucleotides derived from salmon DNA, an advanced technology that I have long been using in my regenerative medicine protocols to improve skin tone, elasticity, and quality.

Public interest grew further after Kim Kardashian, in a recent interview also reported by Vanity Fair Italy, said she tried a salmon DNA-based skin treatment, helping to bring this technology to the general public.

But what are polynucleotides really and why are they becoming one of the most requested treatments in aesthetic medicine?


What are salmon DNA polynucleotides?

Polynucleotides are purified DNA fragments with strong regenerative and biostimulatory properties. In my clinical practice, they are used for specific purposes:

  • Stimulate fibroblast activity
  • To promote the production of collagen and elastin
  • Improve deep hydration and skin quality
  • Protect the skin from oxidative stress

The DNA used comes from salmon because it has a great biological affinity with human DNA, making it highly biocompatible and safe. The result is firmer, brighter, and healthier skin, without altering the features in the slightest.


Biorestructuring: What it really means

When I talk about skin biorestructuring, I am referring to a different concept than classic filling treatments. The goal is not to fill, but to regenerate the skin from within.

Through polynucleotides it is possible to make the skin more elastic and resistant, obtaining a glow effect Natural. It's a treatment I often recommend to patients who want natural results, without distorting their face.


Who do I recommend this treatment to?

Biorestructuring with polynucleotides is indicated for those who present:

  • Dull or dehydrated skin
  • Loss of tone and first signs of aging
  • Skin stressed by the sun or pollution
  • Need for prevention of skin aging

How the treatment is carried out

The treatment consists of superficial microinjections. The session lasts approximately 20–30 minutes and does not require significant recovery time. I generally recommend a protocol of 3–4 sessions to obtain a progressive result.


Regenerative aesthetic medicine: the future

In my clinical approach I often prefer to combine multiple technologies for perfect synergy:

  • Polynucleotides and biostimulating hyaluronic acid
  • Microneedling and Exosomes

The secret is not the single treatment, but the protocol

In my work, I strongly believe in personalized approaches. There is no one-size-fits-all treatment: every skin type requires a specific approach. Biorestructuring is one of the most effective tools, but the best results are always achieved through a personalized approach.

The expert answers: common doubts about biorestructuring

What are the differences with normal fillers?
They perform different functions and have different goals. While fillers fill a void, polynucleotides they take care of the fabric. I choose them for patients who want authentic rejuvenation and visibly healthier skin.
What should I expect immediately after the session in your office?
My microinjection technique aims to minimize discomfort. It's normal to notice small raised bumps (wheals) that fade on their own within a few hours. It's a "lunchtime" treatment: you can return to your daily activities almost immediately, with your skin starting to work internally right away.
What is the ideal age to begin this regenerative journey?
In regenerative medicine, prevention is key. I recommend this treatment for people over 30 to maintain collagen reserves, but the most dramatic results are achieved on mature or photo-aging skin, where the skin's ability to repair itself is slowed and requires effective external stimulation.
Is it true that salmon DNA is Kim Kardashian's secret?
News reports often emphasize curious aspects, but the scientific evidence is more solid. Although international celebrities have highlighted this treatment, I use it in my clinical practice because the data demonstrate real fibroblast stimulation. It's science applied to beauty, beyond the current trend.
How do I integrate polynucleotides into my combination protocols?
I often use biorestructuring as a "base" to prepare the skin for other treatments, such as Botox or deep peels. Regenerated and hydrated skin responds much better to any other aesthetic procedure, making the entire rejuvenation process more natural and long-lasting.
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About

Dr. Maurizio Amato, Born in Naples and raised in a family of doctors, he specializes in nose and breast surgery, and facial rejuvenation. He is known for his advanced and personalized approach, with original techniques published in international scientific journals. He also specializes in secondary surgery, tackling complex cases with expertise and experience. He practices in Naples, where he consults in his office and operates in the city's leading private clinics.

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